Description

(2S,3R)-2-Amino-3-Hydroxy-Butanedioic Acid CAS NO 1186-90-9 is a high-purity, stereochemically defined amino acid derivative, also known as L-threo-3-Hydroxyaspartic acid. This compound serves as a critical chiral building block and biochemical research tool, valued for its role in modulating NMDA receptor activity and studying excitatory amino acid transporters. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical synthesis sectors who require precise stereochemistry and high-quality intermediates for drug discovery and advanced material development.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of novel neuroactive compounds, including NMDA receptor antagonists and modulators.
• Biochemical Research: Used as a selective agonist or substrate analog in neuroscience research to study glutamate receptors and transporters.
• Peptide Synthesis: Incorporated into synthetic peptides to introduce specific stereochemical and functional properties for biological activity studies.
• Enzyme Inhibition Studies: Serves as a potential inhibitor or substrate for enzymes involved in amino acid metabolism, such as aspartate aminotransferase.
• Reference Standard: Utilized as an analytical standard in HPLC, LC-MS, and NMR for method development and quality control in pharmaceutical analysis.
• Fine Chemical Synthesis: Building block for the synthesis of complex organic molecules, natural products, and specialty chemicals requiring the L-threo configuration.

Basic Information

Product Name	(2S,3R)-2-Amino-3-Hydroxy-Butanedioic Acid
CAS No.	1186-90-9
Molecular Formula	C4H7NO5
Molecular Weight	149.10 g/mol
Synonyms	L-threo-3-Hydroxyaspartic acid; (2S,3R)-3-Hydroxyaspartic acid; L-erythro-3-Hydroxyaspartate; 3-Hydroxy-L-aspartic acid; HOAsp; (2S,3R)-2-Amino-3-hydroxybutanedioic acid; 3-Hydroxy-DL-aspartic acid (mixture reference); β-Hydroxyaspartic acid
EINECS	214-673-8

Quality Control

Our (2S,3R)-2-Amino-3-Hydroxy-Butanedioic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to prevent degradation and clumping. For long-term storage, consider using inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (2S,3R) isomer
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.