Description

5-Hydroxy-6-Hydrothymine is a specialized pyrimidine derivative of significant interest in biochemical and pharmaceutical research. This compound serves as a key intermediate and reference standard in the study of nucleic acid chemistry and oxidative DNA damage. It is primarily utilized by research institutions, diagnostic manufacturers, and pharmaceutical companies engaged in advanced analytical chemistry, biomarker discovery, and the development of therapeutic agents targeting oxidative stress pathways.

Application

• Biochemical Research: Critical intermediate for studying thymine glycol formation and DNA oxidation mechanisms.
• Analytical Standard: High-purity reference material for HPLC, LC-MS, and GC-MS analysis in forensic and clinical toxicology.
• Diagnostic Development: Used in the synthesis and calibration of assays for detecting oxidative stress biomarkers in biological fluids.
• Pharmaceutical Intermediates: Serves as a building block in the research and development of novel nucleoside analogs and potential chemotherapeutic agents.
• Academic Studies: Employed in university and institutional labs for fundamental research on free radical biology and radiation chemistry.

Basic Information

Product Name	5-Hydroxy-6-Hydrothymine
CAS No.	1123-21-3
Molecular Formula	C5H8N2O3
Molecular Weight	144.13 g/mol
Synonyms	5,6-Dihydroxy-5,6-dihydrothymine; Thymine Glycol; 5-Hydroxy-5,6-dihydrothymine; 6-Hydroxy-5,6-dihydrothymine; 5,6-Dihydroxydihydrothymine; 5,6-Dihydroxy-5-methylhydrouracil; (5R,6S)-5,6-Dihydroxy-5-methyl-1,3-diazinane-2,4-dione
EINECS	Contact for details

Quality Control

Our 5-Hydroxy-6-Hydrothymine is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.