Description

o-Phospho-L-Threonine is a phosphorylated derivative of the essential amino acid L-threonine, serving as a key biochemical intermediate. This compound is critical for research and development in signal transduction pathways, as it mimics a post-translational modification central to protein function and regulation. It is primarily utilized by biotechnology firms, academic research institutions, and pharmaceutical companies engaged in kinase/phosphatase studies, metabolic research, and the development of cell culture media.

Application

• Biochemical Research: Used as a standard, substrate, or inhibitor in studies of protein kinases, phosphatases, and metabolic enzymes.
• Cell Culture & Media Supplement: Employed as a specialized nutrient component in advanced mammalian cell culture systems to study phosphorylation-dependent growth and signaling.
• Pharmaceutical Development: Serves as a building block or reference compound in drug discovery programs targeting phosphorylation-related diseases.
• Enzymology Studies: Acts as a crucial reagent for investigating enzyme kinetics and mechanisms involving phospho-amino acid metabolism.
• Diagnostic Reagent Manufacturing: Used in the formulation of diagnostic kits and assays that detect or quantify kinase activity or phospho-protein levels.

Basic Information

Product Name	o-Phospho-L-Threonine
CAS No.	1114-81-4
Molecular Formula	C4H10NO6P
Molecular Weight	199.10 g/mol
Synonyms	L-Threonine O-phosphate; Phosphothreonine; (2S,3R)-2-Amino-3-phosphonoxybutanoic acid; O-Phosphonothreonine; Threonine phosphate; Phosphorylated threonine; 3-O-Phosphono-L-threonine; L-Threonine, O-phosphate ester
EINECS	214-214-7

Quality Control

Our o-Phospho-L-Threonine is produced under a rigorous quality management system. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, store in a cool, dry place at controlled room temperature (15-25°C). For long-term stability, consider storage under desiccant or in a nitrogen atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 5.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.