Description

n-Acetyl-D-Methionine is a chemically modified derivative of the essential amino acid D-methionine, characterized by its acetylated amino group. This modification enhances its stability and alters its metabolic pathway, making it a valuable chiral building block and intermediate for specialized synthesis. It is primarily utilized in pharmaceutical research, the development of nutritional supplements, and as a precursor in fine chemical manufacturing. Industries focused on advanced life science applications and high-purity chemical production are the key consumers of this material.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of specialized APIs (Active Pharmaceutical Ingredients) and peptide-based drugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies and metabolic pathway investigations.
• Nutritional Science: Employed in research for developing stabilized amino acid formulations and studying acetylated amino acid bioavailability.
• Peptide Synthesis: Acts as a protected form of D-methionine in solid-phase and solution-phase peptide synthesis to prevent racemization.
• Cosmetic & Personal Care: Investigated for use in high-end skincare formulations for its potential role in antioxidant and protein synthesis pathways.
• Fine Chemical Production: A starting material for the manufacture of other customized N-acetyl amino acid derivatives and chiral compounds.

Basic Information

Product Name	n-Acetyl-D-Methionine
CAS No.	1109-92-8
Molecular Formula	C7H13NO3S
Molecular Weight	191.25 g/mol
Synonyms	N-Acetyl-D-methionine; D-Methionine, N-acetyl-; (R)-2-Acetamido-4-(methylthio)butanoic acid; N-Acetyl-(R)-methionine; Ac-D-Met-OH; (2R)-2-Acetamido-4-methylsulfanylbutanoic acid; NSC 3346; Ac-D-Methionine
EINECS	214-185-6

Quality Control

Our n-Acetyl-D-Methionine is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets exacting standards for research and production. While typically supplied as a high-purity grade suitable for laboratory and industrial use, production can be aligned with specific customer requirements. A Certificate of Analysis (COA) detailing purity, specific rotation, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% D-isomer
Specific Rotation [α]20/D	-20.0° to -24.0° (c=1 in H2O)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.