Description

n-Acetyl-3,5-Diiodo-L-Tyrosine is a halogenated derivative of the amino acid tyrosine, specifically modified with an acetyl group and two iodine atoms. This compound serves as a crucial synthetic intermediate and biochemical research tool, valued for its role in the study and synthesis of thyroid hormones and other iodinated biomolecules. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in endocrinology and metabolic research.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of thyroid hormone analogs and other iodinated active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a substrate or precursor in enzymatic studies, particularly those involving tyrosine metabolism and iodination processes.
• Radiopharmaceutical Development: Serves as a precursor for the development of iodine-123 or iodine-131 labeled compounds for diagnostic imaging or therapy.
• Reference Standard: Employed as a high-purity analytical standard in HPLC and LC-MS methods for quality control and metabolic studies.
• Peptide Synthesis: Can be incorporated into specialized peptides to study structure-activity relationships or to create novel biomaterials.

Basic Information

Product Name	n-Acetyl-3,5-Diiodo-L-Tyrosine
CAS No.	1027-28-7
Molecular Formula	C11H11I2NO4
Molecular Weight	474.02 g/mol
Synonyms	Acetyl-3,5-diiodotyrosine; 3,5-Diiodo-N-acetyl-L-tyrosine; N-Acetyl-3,5-diiodo-L-tyrosine; 2-Acetamido-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid; ADIT; (2S)-2-Acetamido-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid; NSC 403697; L-Tyrosine, N-acetyl-3,5-diiodo-
EINECS	213-838-8

Quality Control

Our n-Acetyl-3,5-Diiodo-L-Tyrosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to handle under an inert atmosphere for long-term storage and to minimize headspace in opened containers.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Specific Rotation	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.