Description

7-Hydroxytheophyllin [German] CAS NO 1012-82-4 is a key xanthine derivative and a significant metabolite of theophylline, serving as a crucial intermediate in pharmaceutical synthesis and research. Its importance lies in its role as a building block for developing novel therapeutic agents and as a reference standard for analytical and metabolic studies. This high-purity compound is essential for pharmaceutical R&D laboratories, analytical chemists, and manufacturers specializing in respiratory and cardiovascular drug development.

Application

• Pharmaceutical Intermediate: Primary use as a critical synthetic precursor in the manufacture of advanced theophylline derivatives and related xanthine-based drugs.
• Metabolite Reference Standard: Essential for use as a certified reference material (CRM) in bioanalytical methods, pharmacokinetic studies, and therapeutic drug monitoring (TDM) for theophylline.
• Biochemical Research: Used in studies investigating adenosine receptor antagonism, phosphodiesterase (PDE) inhibition, and the metabolic pathways of methylxanthines.
• Analytical Chemistry: Serves as a high-purity standard for calibrating HPLC, LC-MS, and other chromatographic systems in pharmaceutical quality control and forensic toxicology labs.
• Academic & Contract Research: A vital reagent for universities and CROs (Contract Research Organizations) conducting medicinal chemistry and drug metabolism research.

Basic Information

Product Name	7-Hydroxytheophyllin [German] CAS NO 1012-82-4
CAS No.	1012-82-4
Molecular Formula	C7H8N4O3
Molecular Weight	196.16 g/mol
Synonyms	7-Hydroxytheophylline; 1,3-Dimethyl-7-hydroxy-3,7-dihydro-1H-purine-2,6-dione; 1,3-Dimethyluric acid; 7-Hydroxy-1,3-dimethylxanthine; Paraxanthine metabolite; U-937; 1,3-Dimethyl-7-hydroxypurine-2,6-dione; 7-Hydroxy-1,3-dimethyl-2,6-dioxopurine
EINECS	213-793-9

Quality Control

Our 7-Hydroxytheophyllin is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and synthesis. Each lot undergoes comprehensive analytical testing including HPLC purity assay, identity confirmation (IR, MS), and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support compliance with ICH guidelines for stability and impurity profiling.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept tightly sealed in a low-humidity environment. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.