Description

4-Hydroxyphenylpyruvic Acid (CAS NO 156-39-8) is a key aromatic keto acid that serves as a crucial biochemical intermediate. Its primary commercial value lies in its role as a versatile precursor in the synthesis of pharmaceuticals, fine chemicals, and advanced research compounds. This product is essential for manufacturers and research institutions in the pharmaceutical, biotechnology, and nutraceutical sectors, particularly those focused on metabolic pathway research and tyrosine derivative synthesis.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of L-DOPA (Levodopa) and other catecholamine-based active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a substrate in enzymatic studies, particularly for research involving the enzyme 4-hydroxyphenylpyruvate dioxygenase (HPPD) and tyrosine metabolism pathways.
• Fine Chemical Synthesis: Serves as a starting material for the production of various aromatic compounds, flavors, and fragrances.
• Nutraceutical Development: Investigated for use in metabolic health supplements and as a precursor in the biosynthesis of natural products.
• Diagnostic Reagent Manufacturing: Employed in the formulation of reagents for clinical diagnostics related to metabolic disorders like tyrosinemia.
• Agrochemical Research: Studied as a lead compound or intermediate in the development of novel HPPD-inhibitor herbicides.

Basic Information

Product Name	4-Hydroxyphenylpyruvic Acid
CAS No.	156-39-8
Molecular Formula	C9H8O4
Molecular Weight	180.16 g/mol
Synonyms	p-Hydroxyphenylpyruvic Acid; (4-Hydroxyphenyl)pyruvic Acid; 4-HPPA; HPPA; 4-Hydroxybenzene pyruvate; 2-Oxo-3-(4-hydroxyphenyl)propanoic acid; 3-(4-Hydroxyphenyl)-2-oxopropanoic acid; 4-Hydroxyphenylpyruvate
EINECS	205-854-8

Quality Control

Our 4-Hydroxyphenylpyruvic Acid is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical and research applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We can supply material compliant with various pharmacopeial standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized; for long-term storage, an inert atmosphere (e.g., nitrogen or argon) is recommended to maintain stability and purity. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	220 - 225 °C (dec.)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.