Description

4-Amino-2-chloro-5-fluoropyrimidine is a high-purity fluorinated pyrimidine building block essential for advanced organic synthesis. This compound matters as a critical intermediate in the development of active pharmaceutical ingredients (APIs), particularly for antiviral and anticancer therapies. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex heterocyclic molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of nucleoside analogs and other fluorinated drug candidates.
• Antiviral Drug Development: Used in research and production of compounds targeting viral enzymes.
• Agrochemical Synthesis: Serves as a building block for novel herbicides and fungicides containing fluoropyrimidine motifs.
• Chemical Research: Employed in academic and industrial R&D for exploring new heterocyclic chemistry and material science.
• Fluorinated Compound Libraries: Used in combinatorial chemistry and high-throughput screening to create diverse molecular libraries for drug discovery.

Basic Information

Product Name	4-Amino-2-chloro-5-fluoropyrimidine
CAS No.	155-10-2
Molecular Formula	C4H3ClFN3
Molecular Weight	147.54 g/mol
Synonyms	2-Chloro-5-fluoro-4-pyrimidinamine; 5-Fluoro-2-chloropyrimidin-4-amine; 2-Chloro-5-fluoropyrimidin-4-ylamine; 4-Amino-2-chloro-5-fluoropyrimidine; 2-Chloro-5-fluoro-4-aminopyrimidine; 5-Fluoro-2-chloro-4-pyrimidinamine; ACFP; 155-10-2
EINECS	Contact for details

Quality Control

Our 4-Amino-2-chloro-5-fluoropyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.