Description

5-Chloro-Dl-Tryptophan is a halogenated derivative of the essential amino acid tryptophan, distinguished by a chlorine atom at the 5-position of the indole ring. This modification significantly alters its biochemical properties, making it a valuable non-natural amino acid for advanced research and synthesis. It serves as a critical chiral building block and biochemical probe for pharmaceutical development, particularly in neuroscience and metabolic studies. Industries requiring custom peptide synthesis, medicinal chemistry research, and biochemical assay development are the primary users of this specialized compound.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of novel drug candidates targeting neurological and psychiatric disorders.
• Biochemical Research: Used as a probe to study enzyme mechanisms, particularly those involving tryptophan metabolism and halogenase activity.
• Peptide Synthesis: Incorporated into custom peptides to modulate their structure, stability, and biological activity for research purposes.
• Metabolic Pathway Analysis: Serves as a tracer or inhibitor in studies of tryptophan and serotonin biosynthesis pathways.
• Medicinal Chemistry: Utilized in structure-activity relationship (SAR) studies to develop compounds with enhanced binding affinity or selectivity.
• Reference Standard: Acts as an analytical standard for quality control and method development in pharmaceutical laboratories.

Basic Information

Product Name	5-Chloro-Dl-Tryptophan
CAS No.	154-07-4
Molecular Formula	C11H11ClN2O2
Molecular Weight	238.67 g/mol
Synonyms	5-Chlorotryptophan; DL-5-Chlorotryptophan; (±)-5-Chlorotryptophan; 2-Amino-3-(5-chloro-1H-indol-3-yl)propanoic acid; 5-Chloro-DL-tryptophan; 5-Cl-DL-Trp; 5-Chloro-DL-Trp; (RS)-5-Chlorotryptophan
EINECS	205-819-8

Quality Control

Our 5-Chloro-Dl-Tryptophan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, chiral analysis, and identity confirmation to ensure it meets the stringent requirements for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and impurity profiles. We support compliance with relevant guidelines for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	DL-mixture (racemic)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.