Description

A-Methyl-L-Tryptophan is a non-proteinogenic amino acid derivative of L-tryptophan, characterized by a methyl group substitution at the α-carbon position. This structural modification makes it a valuable chiral building block and a critical intermediate in the synthesis of more complex bioactive molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for applications ranging from metabolic pathway studies to the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and production of peptide-based drugs, enzyme inhibitors, and other bioactive compounds.
• Biochemical Research: Used as a standard or reagent in metabolic studies, particularly those investigating tryptophan metabolism and related pathways.
• Peptide Synthesis: Employed as a modified amino acid building block in solid-phase and solution-phase peptide synthesis to introduce specific structural features.
• Enzyme Inhibition Studies: Acts as a potential inhibitor or substrate analog in enzymatic assays to study enzyme mechanisms and kinetics.
• Reference Standard: Utilized as a high-purity analytical standard in quality control laboratories for method development and validation (HPLC, LC-MS).
• Fine Chemical Synthesis: A precursor in the multistep synthesis of complex organic molecules for agrochemical and material science applications.

Basic Information

Product Name	A-Methyl-L-Tryptophan
CAS No.	153-91-3
Molecular Formula	C12H14N2O2
Molecular Weight	218.25 g/mol
Synonyms	(S)-2-Amino-3-(1H-indol-3-yl)-2-methylpropanoic acid; (S)-α-Methyltryptophan; L-α-Methyltryptophan; AMT; 1H-Indole-3-propanoic acid, α-amino-α-methyl-, (αS)-; NSC 143491; (S)-2-Methyltryptophan; α-Methyl-L-tryptophan
EINECS	205-823-7

Quality Control

Our A-Methyl-L-Tryptophan is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing specific results for identity, purity, and related substances are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-Isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.