Description

L-Tetrahydrofolic Acid is the biologically active, reduced form of folic acid (vitamin B9) and serves as a critical coenzyme in one-carbon transfer reactions essential for nucleotide synthesis and amino acid metabolism. Its high purity and stability are paramount for ensuring efficacy in advanced pharmaceutical and nutraceutical formulations. This compound is primarily required by manufacturers in the pharmaceutical, dietary supplement, and advanced biochemical research sectors for producing high-grade active pharmaceutical ingredients (APIs) and premium nutritional products.

Application

• Pharmaceutical Active Ingredient (API): Core component in prescription medications and injectables targeting folate deficiency and supporting metabolic pathways.
• Dietary Supplement Formulation: Key ingredient in high-potency prenatal vitamins, B-complex supplements, and specialized nutraceuticals for enhanced bioavailability.
• Cell Culture & Biomedical Research: Essential growth factor in cell culture media and a critical reagent in studies of DNA synthesis, methylation, and cellular metabolism.
• Clinical & Diagnostic Reagents: Used in the production of diagnostic kits and assay standards for measuring folate levels in clinical settings.
• Fortification of Medical Foods: Incorporation into medical nutrition products designed for specific dietary management and metabolic disorders.
• Biochemical Synthesis: Serves as a cofactor and intermediate in enzymatic synthesis and biocatalysis processes.

Basic Information

Product Name	L-Tetrahydrofolic Acid
CAS No.	135-16-0
Molecular Formula	C19H23N7O6
Molecular Weight	445.43 g/mol
Synonyms	(6S)-Tetrahydrofolic Acid; (6S)-5,6,7,8-Tetrahydrofolic Acid; L-5,6,7,8-Tetrahydrofolate; Levomefolic Acid; 5,6,7,8-Tetrahydro-L-folate; Metafolin; (6S)-THFA; Active Folate
EINECS	205-181-5

Quality Control

Our L-Tetrahydrofolic Acid is manufactured under strict quality systems. Each batch is subjected to rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical and nutraceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store unopened vials at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. For daily use, store desiccated at 2-8°C. This material is strictly light-sensitive, easily oxidized, and hygroscopic; therefore, it must be handled in a controlled environment to minimize exposure to light, air, and moisture.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC/UV)	Conforms to reference standard
Assay (HPLC)	≥ 97.0%
Optical Rotation	[α]20/D: +14.0° to +20.0° (c=1, 0.1N NaOH)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.