Description

5-Methyltetrahydrofolic Acid (CAS NO 134-35-0) is the predominant, metabolically active form of folate in human circulation and a critical cofactor in one-carbon metabolism. This high-purity compound is essential for applications requiring a bioavailable and stable source of folate that bypasses the need for enzymatic conversion. It is primarily sought by manufacturers in the pharmaceutical and advanced nutraceutical sectors for premium-grade formulations.

Application

• Pharmaceutical Active Ingredient: Used in prescription and high-dose therapeutic formulations for folate deficiency and in targeted metabolic support.
• Premium Dietary Supplements: A key ingredient in advanced prenatal vitamins, cognitive health, and cardiovascular support supplements due to its superior bioavailability.
• Clinical & Research Nutrition: Incorporated into medical foods and clinical nutrition products for patients with specific metabolic polymorphisms (e.g., MTHFR).
• Biochemical Research: Serves as a critical reagent in enzymatic studies, cell culture media supplementation, and metabolic pathway research.
• Cosmeceuticals: Formulated into high-end skincare products for its potential role in cellular repair and antioxidant protection.
• Reference Standard: Used as a high-purity calibration standard in analytical laboratories for HPLC and LC-MS methods.

Basic Information

Product Name	5-Methyltetrahydrofolic Acid
CAS No.	134-35-0
Molecular Formula	C20H25N7O6
Molecular Weight	459.46 g/mol
Synonyms	(6S)-5-Methyltetrahydrofolic Acid; (6S)-5-Methyltetrahydrofolate; 5-MTHF; L-Methylfolate; Metafolin® (brand name); 5-Methyl-5,6,7,8-tetrahydrofolic acid; 5-Methyl-H4-folate; Levomefolic Acid
EINECS	205-142-1

Quality Control

Our 5-Methyltetrahydrofolic Acid is manufactured under strict quality systems. Each batch is tested to ensure it meets stringent specifications for identity, purity, and potency, suitable for pharmaceutical and nutraceutical applications. A comprehensive Certificate of Analysis (COA) detailing HPLC assay, chiral purity, and related substance profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep the container in a dry, cool, and well-ventilated area.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (6S)-isomer
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.