Description

cis-4-Hydroxy-L-Proline is a non-proteinogenic amino acid derivative, specifically a hydroxylated form of L-proline. This compound is a critical chiral building block and intermediate in organic synthesis and pharmaceutical manufacturing. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries, particularly for the development of peptide-based drugs, collagen research, and as a precursor for complex bioactive molecules.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of angiotensin-converting enzyme (ACE) inhibitors, antiviral agents, and other active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to introduce conformational constraints and modify peptide properties.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies and as a standard in collagen and hydroxyproline metabolism research.
• Cosmetic & Nutraceutical Ingredients: Employed in the formulation of anti-aging skincare products and nutraceuticals targeting collagen synthesis and skin health.
• Asymmetric Catalysis: Utilized as a ligand or catalyst component in asymmetric synthesis due to its rigid, chiral structure.
• Cell Culture Media: Component in specialized cell culture media, particularly for mammalian cell lines requiring proline and its derivatives.

Basic Information

Product Name	cis-4-Hydroxy-L-Proline
CAS No.	618-27-9
Molecular Formula	C5H9NO3
Molecular Weight	131.13 g/mol
Synonyms	(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid; L-4-Hydroxyproline; (4R)-4-Hydroxy-L-proline; 4-Hydroxy-L-proline; Hyp; L-Hydroxyproline; trans-4-Hydroxy-L-proline (Note: The 'cis' isomer is less common; this CAS typically refers to the (2S,4R) isomer, often termed 'trans' in peptide literature. Please confirm stereochemistry for your application.)
EINECS	210-548-9

Quality Control

Our cis-4-Hydroxy-L-Proline is manufactured under strict quality management systems. We offer various grades, including standard, high-purity, and pharmaceutical intermediates, with quality specifications tailored to customer requirements. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. Our quality commitment ensures compliance with relevant standards for research and industrial use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent absorption of moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Specific Rotation	-74° to -78° (c=1 in H2O)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.