Description

L-Histidine Hydrochloride Monohydrate is a high-purity amino acid derivative essential for numerous biochemical and industrial processes. This compound serves as a critical building block in pharmaceutical formulations and nutritional supplements, offering superior stability and bioavailability. It is primarily utilized by manufacturers in the pharmaceutical, nutraceutical, and research sectors for applications requiring a reliable source of the essential amino acid L-Histidine.

Application

• Pharmaceutical Intermediates: A key raw material in the synthesis of active pharmaceutical ingredients (APIs) and peptide drugs.
• Infusion & Parenteral Nutrition: An essential component in amino acid solutions for clinical nutrition and intravenous feeding.
• Dietary Supplements & Sports Nutrition: Used in protein powders, amino acid blends, and specialized nutritional products.
• Cell Culture Media: A vital nutrient component in media formulations for biotechnology and mammalian cell culture.
• Biochemical Research: Employed as a standard and reagent in enzymatic studies, metabolic research, and protein chemistry.
• Cosmetic & Personal Care: Incorporated into skincare formulations for its potential moisturizing and buffering properties.

Basic Information

Product Name	L-Histidine Hydrochloride Monohydrate
CAS No.	5934-29-2
Molecular Formula	C6H9N3O2 • HCl • H2O
Molecular Weight	209.63 g/mol
Synonyms	L-Histidine HCl Monohydrate; Histidine Hydrochloride Monohydrate; (S)-2-Amino-3-(1H-imidazol-4-yl)propanoic acid hydrochloride monohydrate; H-His-OH•HCl•H2O; L-Histidine, hydrochloride, monohydrate; Histidine monohydrochloride monohydrate; L-Histidine HCl H2O
EINECS	227-695-8

Quality Control

Our L-Histidine Hydrochloride Monohydrate is manufactured under strict quality management systems. Each batch is tested to ensure compliance with relevant pharmacopeial standards such as USP, EP, and JP, where applicable. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and consistent quality for your production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Specific Rotation [α]D20	+9.5° to +11.5° (c=2 in 6N HCl)
pH (5% solution)	3.0 - 4.0
Loss on Drying	7.0% - 9.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.