Description

Histamine Dihydrochloride is a high-purity salt form of the essential biogenic amine, histamine. This compound is a critical biochemical reagent and pharmaceutical intermediate, valued for its stability and solubility in aqueous systems. It is primarily utilized in research, diagnostic manufacturing, and the development of therapeutic agents targeting allergic and inflammatory responses.

Application

• Pharmaceutical Research & Development: As a key reference standard and active pharmaceutical ingredient (API) intermediate in the synthesis of anti-allergy and anti-ulcer medications.
• Diagnostic Manufacturing: Used in the production of immunoassay kits and reagents for the quantitative determination of histamine and related antibodies.
• Biochemical Research: Essential for studying histamine receptors (H1, H2, H3, H4), signal transduction pathways, and inflammatory processes in vitro and in vivo.
• Quality Control & Standardization: Serves as a primary standard for calibrating analytical instruments (HPLC, GC) and validating methods in pharmaceutical QC laboratories.
• Cell Culture & Physiology Studies: Employed to stimulate physiological responses in cell-based assays and tissue preparations.

Basic Information

Product Name	Histamine Dihydrochloride
CAS No.	56-92-8
Molecular Formula	C5H9N3·2HCl
Molecular Weight	184.07 g/mol
Synonyms	Histamine 2HCl; 2-(1H-Imidazol-4-yl)ethanamine dihydrochloride; 4-(2-Aminoethyl)imidazole dihydrochloride; Ergamine dihydrochloride; 1H-Imidazole-4-ethanamine, dihydrochloride; Histamine HCl; Histamine Chloride
EINECS	200-299-1

Quality Control

Our Histamine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) providing purity, identity, and impurity profiles is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.