Description

5-Aminolevulinic Acid Hydrochloride is a key biochemical precursor in the heme biosynthesis pathway. This compound is of significant commercial and research interest due to its role as a prodrug in photodynamic therapy and diagnostics. It is primarily utilized by the pharmaceutical, biotechnology, and agricultural research sectors for developing novel therapeutics, studying plant physiology, and in biochemical synthesis.

Application

• Photodynamic Therapy (PDT): As a prodrug, it is metabolized into protoporphyrin IX, a potent photosensitizer used in the clinical treatment of actinic keratosis, basal cell carcinoma, and other dermatological conditions.
• Agricultural Research: Employed in studies of plant growth regulation, herbicide development, and as an inducer of porphyrin accumulation for studying plant stress responses.
• Biochemical Synthesis: Serves as a crucial building block in the laboratory synthesis of porphyrins, vitamin B12 analogs, and other tetrapyrrole compounds.
• Diagnostic Agent: Used in fluorescence-guided surgery and the detection of malignant tissues, where its metabolic product aids in visualizing tumor margins.
• Microbiological Studies: Applied in research concerning bacterial heme biosynthesis and the development of antimicrobial strategies targeting this pathway.
• Cosmeceutical Research: Investigated for potential use in topical formulations aimed at skin rejuvenation and acne treatment due to its effect on cellular metabolism.

Basic Information

Product Name	5-Aminolevulinic Acid Hydrochloride
CAS No.	5451-09-2
Molecular Formula	C5H9NO3 • HCl
Molecular Weight	167.59 g/mol (Free base: 131.13)
Synonyms	5-ALA HCl; δ-Aminolevulinic Acid Hydrochloride; 5-Amino-4-oxopentanoic Acid Hydrochloride; Levulinic acid, 5-amino-, hydrochloride; ALA HCl; 5-Aminolaevulinic Acid Hydrochloride; Aminolevulinic Acid HCl
EINECS	226-662-3

Quality Control

Our 5-Aminolevulinic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and stringent controls for residual solvents and heavy metals. Certificates of Analysis (COA) documenting compliance with in-house specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the certificate of analysis. Due to its hygroscopic and light-sensitive nature, the container should be allowed to reach room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.