Description

Histamine CAS NO 51-45-6 is a critical biogenic amine and a fundamental signaling molecule in numerous physiological and pathological processes. Its precise purity and stability are paramount for research and diagnostic applications where reliable and consistent results are essential. This compound is primarily utilized by the pharmaceutical, biotechnology, and life science research sectors for drug discovery, immunological studies, and as a reference standard in analytical testing.

Application

• Pharmaceutical Research & Development: Used as a key reference standard and active agent in the development and testing of antihistamine drugs, allergy treatments, and gastrointestinal medications.
• Immunological & Biochemical Research: Serves as a vital tool for studying inflammatory responses, anaphylaxis, gastric acid secretion, and neurotransmission in model systems.
• Diagnostic Reagent Manufacturing: Employed in the production of calibration standards and reagents for clinical diagnostic kits, particularly those related to allergy testing and histamine level assays.
• Cell Culture & In Vitro Studies: Applied in cell-based assays to investigate receptor function (H1, H2, H3, H4 receptors) and intracellular signaling pathways.
• Food Safety & Quality Control: Used as an analytical standard to detect and quantify histamine levels in food products (e.g., fish, fermented foods) for spoilage and safety monitoring.
• Neuroscience Research: Fundamental for studies exploring its role as a neurotransmitter in the central nervous system and its implications in sleep-wake cycles and other brain functions.

Basic Information

Product Name	Histamine
CAS No.	51-45-6
Molecular Formula	C5H9N3
Molecular Weight	111.15 g/mol
Synonyms	2-(1H-Imidazol-4-yl)ethanamine; 2-(4-Imidazolyl)ethylamine; 4-(2-Aminoethyl)imidazole; Ergamine; Histamine base; 1H-Imidazole-4-ethanamine; β-Aminoethylglyoxaline; Enteramine; Histaminum
EINECS	200-100-6

Quality Control

Our Histamine is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency suitable for research and industrial applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While we offer various grades, our standard product meets specifications typical for research and analytical use. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.