Description

D-Histidine is a non-proteinogenic, enantiomerically pure form of the essential amino acid L-histidine, distinguished by its D-configuration. This specific stereochemistry makes it a valuable chiral building block and analytical standard in advanced biochemical research and pharmaceutical development. It is primarily utilized by research institutions, diagnostic manufacturers, and companies developing peptide-based therapeutics and nutritional supplements.

Application

• Pharmaceutical Research: Serves as a critical chiral precursor in the synthesis of novel peptide drugs and active pharmaceutical ingredients (APIs).
• Biochemical Standard: Used as a high-purity reference standard in analytical methods like HPLC and mass spectrometry for amino acid analysis.
• Nutritional Science Studies: Employed in metabolic research to study the specific effects and absorption pathways of D-amino acids.
• Diagnostic Reagent Formulation: A key component in manufacturing specialized diagnostic kits and enzymatic assay systems.
• Cosmetic & Personal Care: Incorporated into advanced skincare formulations for its potential bioactive properties.

Basic Information

Product Name	D-Histidine
CAS No.	351-50-8
Molecular Formula	C6H9N3O2
Molecular Weight	155.16 g/mol
Synonyms	(R)-2-Amino-3-(1H-imidazol-4-yl)propanoic acid; D-(-)-Histidine; (R)-Histidine; (2R)-2-Amino-3-(1H-imidazol-5-yl)propanoic acid; H-D-His-OH; D-His; D-Histidine, free base
EINECS	206-513-8

Quality Control

Our D-Histidine is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets high-grade specifications for research and development. Certificates of Analysis (COA) detailing purity, optical rotation, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Optical Rotation	-38.5° to -41.5° (c=1 in H2O)
Chiral Purity (HPLC)	≥ 99.0% D-isomer
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.