Description

D-2-Amino-4-Methylpentanoic Acid is the D-isomer of the branched-chain amino acid leucine. This specific enantiomer is a critical chiral building block and intermediate in the synthesis of pharmaceuticals, peptides, and fine chemicals. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and nutraceutical industries who require high-purity, stereochemically defined raw materials for advanced applications.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for metabolic and neurological drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate the D-leucine residue, which can enhance peptide stability and biological activity.
• Biochemical Research: Serves as a standard and reagent in enzymatic studies, metabolic pathway analysis, and microbiological media preparation.
• Asymmetric Catalysis: Employed as a chiral ligand or precursor in asymmetric synthesis to induce stereoselectivity.
• Nutraceutical Formulation: A component in specialized dietary supplements and clinical nutrition products targeting specific metabolic functions.
• Fine Chemical Production: A building block for synthesizing complex organic molecules, flavors, and fragrances.

Basic Information

Product Name	D-2-Amino-4-Methylpentanoic Acid
CAS No.	328-38-1
Molecular Formula	C6H13NO2
Molecular Weight	131.17 g/mol
Synonyms	D-Leucine; (R)-2-Amino-4-methylpentanoic acid; (R)-Leucine; D-(-)-Leucine; (2R)-2-Amino-4-methylpentanoic acid; H-D-Leu-OH; D-α-Aminoisocaproic acid
EINECS	206-328-2

Quality Control

Our D-2-Amino-4-Methylpentanoic Acid is manufactured under a strict quality management system. Each batch is tested to ensure it meets high-purity standards, with typical grades offering ≥98.5% to 99.5% purity by HPLC. We provide comprehensive Certificates of Analysis (COA) detailing assay, enantiomeric excess, and impurity profiles. Specifications can align with research, pharmaceutical intermediate, or other application-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed to prevent absorption of moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Assay (HPLC)	≥98.5%
Optical Rotation [α]20/D	-14.5° to -16.0° (c=1 in 1N HCl)
Loss on Drying	≤0.5%
Residue on Ignition (Sulfated Ash)	≤0.1%
Heavy Metals (as Pb)	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.