Description

cis-4-Hydroxy-D-Proline is a non-proteinogenic amino acid derivative characterized by its unique stereochemistry and hydroxylated pyrrolidine ring. This compound is a critical chiral building block and intermediate in the synthesis of complex pharmaceuticals and bioactive molecules. It is essential for research and production in the pharmaceutical, biotechnology, and fine chemical industries, where precise stereochemical control is paramount for drug efficacy and safety.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of protease inhibitors, antiviral drugs, and other active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used to introduce conformational constraints and enhance metabolic stability in therapeutic peptide design.
• Biochemical Research: Serves as a standard, reagent, or substrate in enzymatic studies and metabolic pathway investigations.
• Glycopeptide & Antibiotic Synthesis: A vital component in constructing complex natural products like glycopeptide antibiotics.
• Asymmetric Catalysis: Employed as a chiral ligand or auxiliary in stereoselective chemical transformations.
• Cosmetic & Nutraceutical R&D: Investigated for potential applications in collagen synthesis support and anti-aging formulations.

Basic Information

Product Name	cis-4-Hydroxy-D-Proline
CAS No.	2584-71-6
Molecular Formula	C5H9NO3
Molecular Weight	131.13 g/mol
Synonyms	(2R,4R)-4-Hydroxypyrrolidine-2-carboxylic acid; D-4-Hydroxyproline; (R,R)-4-Hydroxyproline; 4-Hydroxy-D-proline; cis-4-Hydroxy-D-proline; HYP-D; D-Hyp-OH; 4(R)-Hydroxy-D-proline
EINECS	219-967-5

Quality Control

Our cis-4-Hydroxy-D-Proline is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.