Description

L-Proline CAS NO 147-85-3 is a non-essential, proteinogenic amino acid characterized by its unique secondary amine structure, which forms a five-membered pyrrolidine ring. This cyclic structure is critical for its role as a key conformational determinant in peptides and proteins, influencing folding, stability, and biological activity. It is an indispensable raw material and intermediate for the pharmaceutical, nutraceutical, and cosmetic industries, where its unique properties are leveraged to develop advanced formulations.

Application

• Pharmaceutical Synthesis: A vital chiral building block and intermediate in the production of APIs (Active Pharmaceutical Ingredients), including ACE inhibitors and other cardiovascular drugs.
• Cell Culture Media: An essential component in mammalian cell culture media, particularly for the biomanufacturing of monoclonal antibodies, vaccines, and other biologics.
• Nutraceuticals & Sports Nutrition: Used in dietary supplements and protein powders for its role in collagen synthesis, joint health support, and muscle recovery.
• Cosmetic Formulations: Incorporated into anti-aging and skin-repair creams and serums for its moisturizing properties and ability to support skin structure.
• Biochemical Research: Serves as a standard and reagent in biochemical research, enzymatic studies, and as a component of buffer systems.
• Food & Flavor Enhancement: Utilized as a flavor modifier and sweetener potentiator in certain food products and flavorings.

Basic Information

Product Name	L-Proline
CAS No.	147-85-3
Molecular Formula	C5H9NO2
Molecular Weight	115.13 g/mol
Synonyms	(S)-Pyrolidine-2-carboxylic acid; (S)-(-)-Proline; L-2-Pyrrolidinecarboxylic acid; (-)-Proline; Proline, L-; (S)-Proline; L-Pyrrolidine-2-carboxylic acid; (2S)-Pyrrolidine-2-carboxylic acid
EINECS	205-702-2

Quality Control

Our L-Proline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the highest standards of identity, purity, and composition. We offer various grades, including Pharmaceutical (USP/EP), Food (FCC), and Research grades, with full traceability. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White crystalline powder
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.5%
Optical Rotation [α]20/D	-84° to -86° (c=1 in H2O)
Loss on Drying	≤ 0.5%
Residue on Ignition (Sulfated Ash)	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Specific Optical Rotation	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.