Alkylating Antineoplastic Agents

Antineoplastics

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Alkylating Antineoplastic Agents

Alkylating antineoplastic agents are cytotoxic APIs that form covalent bonds with DNA, leading to cross-linking, strand breaks, and inhibition of replication and transcription. This class includes nitrogen mustards, nitrosoureas, alkyl sulfonates, triazenes, and platinum-based drugs. They are effective against a wide range of hematologic malignancies and solid tumors such as breast cancer, ovarian cancer, sarcomas, and brain tumors. Their mechanism is cell cycle–nonspecific, making them particularly active against rapidly dividing cells. However, their strong cytotoxicity can result in bone marrow suppression, infertility, and secondary malignancies. Despite these risks, alkylating agents remain foundational drugs in many chemotherapeutic regimens due to their broad antitumor activity.

2-[4-[Bis(2-Chloroethyl)Amino]Phenyl]Ethene-1,1,2-Tricarbonitrile CAS NO 14185-99-0

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CAS No.:14185-99-0

Grade:Pharmacy Grade

Content:99.90%

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n-[[4-[Bis(2-Chloroethyl)Amino]Phenyl]Methylideneamino]-2-(7-Hydroxy-2 -Oxo-Chromen-4-Yl)Acetamide CAS NO 14522-20-4

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CAS No.:14522-20-4

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Content:99.90%

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Dichloroplatinum CAS NO 14647-25-7

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CAS No.:14647-25-7

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Content:99.90%

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2-[Bis(2-Chloroethyl)Amino]-5-Chloro-p-Benzoquinone CAS NO 15482-83-4

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CAS No.:15482-83-4

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Content:99.90%

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Cisplatin CAS NO 15603-27-1

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CAS No.:15603-27-1

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Content:99.90%

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Pentamethylmelamine CAS NO 16268-62-5

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CAS No.:16268-62-5

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Content:99.90%

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2-[1,3-Bis[[4-[Bis(2-Chloroethyl)Amino]Phenyl]Methyl]-1,3-Diazinan-2-Yl]-4-Nitro-Phenol CAS NO 16757-47-4

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CAS No.:16757-47-4

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Content:99.90%

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Oxylidin CAS NO 16852-81-6

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CAS No.:16852-81-6

Grade:Pharmacy Grade

Content:99.90%

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