Description

Miriplatin CAS NO 104276-92-8 is a platinum-based chemotherapeutic agent specifically designed for the treatment of hepatocellular carcinoma (HCC). This compound matters as a targeted therapeutic option, offering a localized treatment approach with a distinct mechanism of action. It is primarily needed by pharmaceutical manufacturers and research institutions developing or producing oncology drugs, particularly for intra-arterial administration in liver cancer therapy.

Application

• Primary Pharmaceutical Ingredient: As the active pharmaceutical ingredient (API) in injectable formulations for the treatment of hepatocellular carcinoma.
• Oncology Research: Used in preclinical and clinical research to study its efficacy, pharmacokinetics, and mechanism of action against various solid tumors.
• Drug Delivery System Development: A candidate for incorporation into novel drug delivery systems, such as liposomes or nanoparticles, to enhance targeting and reduce systemic toxicity.
• Combination Therapy Studies: Investigated in combination with other chemotherapeutic agents or radiotherapy to improve treatment outcomes for liver cancer.
• Reference Standard: Serves as a high-purity chemical reference standard for quality control and analytical method development in pharmaceutical laboratories.

Basic Information

Product Name	Miriplatin
CAS No.	104276-92-8
Molecular Formula	C₃₄H₆₆N₂O₈Pt
Molecular Weight	849.06 g/mol
Synonyms	Miriplatin; SM-11355; (OC-6-43)-Bis[(1R,2R)-1,2-cyclohexanediamine-N,N'] [tetradecanedioato(2-)-κO1,κO2]platinum; Miriplat; cis-[(1R,2R)-1,2-cyclohexanediamine-N,N']bis(tetradecanedioato)platinum(II); SM11355
EINECS	Contact for details

Quality Control

Our Miriplatin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for pharmaceutical use, including identity, purity, and impurity profile. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with in-house specifications aligned with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.