Alkylating Antineoplastic Agents

Alkylating Antineoplastic Agents

Alkylating antineoplastic agents are cytotoxic APIs that form covalent bonds with DNA, leading to cross-linking, strand breaks, and inhibition of replication and transcription. This class includes nitrogen mustards, nitrosoureas, alkyl sulfonates, triazenes, and platinum-based drugs. They are effective against a wide range of hematologic malignancies and solid tumors such as breast cancer, ovarian cancer, sarcomas, and brain tumors. Their mechanism is cell cycle–nonspecific, making them particularly active against rapidly dividing cells. However, their strong cytotoxicity can result in bone marrow suppression, infertility, and secondary malignancies. Despite these risks, alkylating agents remain foundational drugs in many chemotherapeutic regimens due to their broad antitumor activity.

cis-Tetrachlorodiammine Platinum (Iv) CAS NO 16893-05-3

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CAS No.:16893-05-3

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4-[Di(2-Chloroethyl)Amino]-2-Methoxybenzaldehyde CAS NO 17126-76-0

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CAS No.:17126-76-0

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5-[Bis(2-Chloroethyl)Amino]-m-Toluic Acid CAS NO 17191-65-0

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4-N,n-Bis(2-Chloroethyl)Aminophenoxyacetic Acid CAS NO 17528-53-9

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Cynaustine CAS NO 17958-39-3

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CAS No.:17958-39-3

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n-[4-[Bis(2-Chloroethyl)Amino]Phenyl]-2-Oxopropanamide Oxime CAS NO 18237-80-4

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CAS No.:18237-80-4

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3-[Bis(2-Chloroethyl)Amino]-p-Toluic Acid Methyl Ester CAS NO 18583-88-5

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1,3-Dicyclohexyl-1-Nitrosourea CAS NO 18664-26-1

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