Alkylating Antineoplastic Agents

Antineoplastics

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Alkylating Antineoplastic Agents

Alkylating antineoplastic agents are cytotoxic APIs that form covalent bonds with DNA, leading to cross-linking, strand breaks, and inhibition of replication and transcription. This class includes nitrogen mustards, nitrosoureas, alkyl sulfonates, triazenes, and platinum-based drugs. They are effective against a wide range of hematologic malignancies and solid tumors such as breast cancer, ovarian cancer, sarcomas, and brain tumors. Their mechanism is cell cycle–nonspecific, making them particularly active against rapidly dividing cells. However, their strong cytotoxicity can result in bone marrow suppression, infertility, and secondary malignancies. Despite these risks, alkylating agents remain foundational drugs in many chemotherapeutic regimens due to their broad antitumor activity.

1-Hexyl-1-Nitrosourea CAS NO 18774-85-1

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CAS No.:18774-85-1

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Content:99.90%

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4-(4-(Bis-(2-Chloroethyl)Amino)Benzylidene-2-Phenyl-Oxazoline-5-One CAS NO 18776-75-5

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CAS No.:18776-75-5

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Content:99.90%

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2'-O,3'-o-[p-[(2-Chloroethyl)Methylamino]Benzylidene]Uridine CAS NO 18837-80-4

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CAS No.:18837-80-4

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2-Deoxy-2-(3-Methyl-3-Nitrosoureido)-D-Glucopyranose 1,3,4,6-Tetraacetate CAS NO 18977-95-2

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CAS No.:18977-95-2

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3-[Bis(2-Chloroethyl)Amino]-4-Methylbenzamide CAS NO 19768-73-1

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CAS No.:19768-73-1

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3-[Bis(2-Chloroethyl)Amino]-4-Methylbenzene-1-Sulfonic Acid CAS NO 19768-75-3

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CAS No.:19768-75-3

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[3-[Bis(2-Chloroethyl)Amino]-4-Methylphenyl]Phosphonic Acid CAS NO 19768-76-4

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CAS No.:19768-76-4

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N,n-Bis(2-Chloroethyl)Acetamide CAS NO 19945-22-3

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CAS No.:19945-22-3

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Content:99.90%

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