Description

Beta,β-Difluorochlorambucil CAS NO 103638-41-1 is a fluorinated derivative of the classic alkylating agent chlorambucil, designed to enhance metabolic stability and therapeutic potential. This compound is of significant interest for advanced pharmaceutical research and development, particularly in the field of oncology. It serves as a critical intermediate for medicinal chemists and researchers in the pharmaceutical and biotechnology industries who are developing next-generation targeted cancer therapies.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel, fluorinated anti-cancer agents and targeted therapies.
• Oncology Research: Used in biochemical and pharmacological studies to investigate the structure-activity relationship (SAR) of nitrogen mustard derivatives.
• Medicinal Chemistry: Employed in lead optimization programs to improve the pharmacokinetic profile, such as metabolic stability and membrane permeability, of drug candidates.
• Preclinical Development: Serves as a reference standard or an active ingredient in formulation studies for experimental cancer treatments.
• Bioconjugation Studies: Potential use in the development of antibody-drug conjugates (ADCs) due to its alkylating functionality.

Basic Information

Product Name	Beta,β-Difluorochlorambucil
CAS No.	103638-41-1
Molecular Formula	C14H19Cl2F2NO2
Molecular Weight	342.21 g/mol
Synonyms	4-[Bis(2-chloroethyl)amino]benzenebutanoic acid, β,β-difluoro-; β,β-Difluorochlorambucil; 4-[Bis(2-chloroethyl)amino]-β,β-difluorohydrocinnamic acid; NSC 757680; Difluorochlorambucil; Chlorambucil difluoro analog; 2,2-Difluoro-4-[p-[bis(2-chloroethyl)amino]phenyl]butyric acid
EINECS	Contact for details

Quality Control

Our Beta,β-Difluorochlorambucil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.