Description

3-[Amino-[Bis(2-Chloroethyl)Amino]Phosphoryl]Oxy-1-Phenyl-Propan-1-One is a specialized organophosphorus compound featuring a unique nitrogen mustard moiety. This structure makes it a valuable high-purity chemical intermediate for advanced research and synthesis. It is primarily utilized by pharmaceutical R&D and fine chemical sectors for developing novel therapeutic agents and bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block in the research and synthesis of potential anticancer agents and targeted therapies.
• Bioconjugation & Prodrug Development: Used to create antibody-drug conjugates (ADCs) and prodrugs due to its reactive functional groups.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies in drug discovery programs.
• Chemical Biology Probes: Employed in the development of molecular probes to study enzyme inhibition and cellular pathways.
• Fine Chemical Synthesis: Intermediate for producing complex, high-value specialty chemicals with specific biological activities.

Basic Information

Product Name	3-[Amino-[Bis(2-Chloroethyl)Amino]Phosphoryl]Oxy-1-Phenyl-Propan-1-One
CAS No.	100993-68-8
Molecular Formula	C₁₅H₂₁Cl₂N₂O₃P
Molecular Weight	379.22 g/mol
Synonyms	1-Propanone, 3-[amino[bis(2-chloroethyl)amino]phosphinyl]oxy-1-phenyl-; 3-[Amino[bis(2-chloroethyl)amino]phosphoryl]oxy-1-phenylpropan-1-one; Phosphorodiamidic acid, P-[2-(benzoyl)ethyl]-, N,N-bis(2-chloroethyl)-; P-[2-(Benzoyl)ethyl]-N,N-bis(2-chloroethyl)phosphorodiamidate; Nitrogen mustard phosphoramidate prodrug intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your R&D and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to maximize stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.