Description

4-[Bis-(2-Chloro-Ethyl)-Amino]-Dl-Phenylalanine Ethyl Ester, Monohydrochloride is a chemically modified amino acid derivative, specifically a nitrogen mustard conjugate of phenylalanine. This compound is of significant interest in pharmaceutical research and development, particularly as a key intermediate or precursor in the synthesis of targeted chemotherapeutic agents. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in developing novel anti-cancer therapies and exploring prodrug strategies.

Application

• Pharmaceutical Intermediate: A critical building block in the research and synthesis of nitrogen mustard-based chemotherapeutic agents and prodrugs.
• Anticancer Drug Research: Used in the development of targeted therapies that aim to improve selectivity and reduce systemic toxicity in cancer treatment.
• Bioconjugation & Prodrug Synthesis: Serves as a versatile linker or payload in the creation of antibody-drug conjugates (ADCs) and other targeted delivery systems.
• Biochemical Research: Employed in studies investigating alkylating agent mechanisms, DNA interaction, and cell apoptosis pathways.
• Fine Chemical Synthesis: Acts as a specialized intermediate for custom synthesis services catering to the life sciences sector.

Basic Information

Product Name	4-[Bis-(2-Chloro-Ethyl)-Amino]-Dl-Phenylalanine Ethyl Ester, Monohydrochloride
CAS No.	112117-81-4
Molecular Formula	C15H22Cl3N2O2
Molecular Weight	377.70 g/mol
Synonyms	DL-Phenylalanine, 4-[bis(2-chloroethyl)amino]-, ethyl ester, hydrochloride (1:1); Ethyl 4-[bis(2-chloroethyl)amino]phenylalaninate hydrochloride; NSC 363249; Phenylalanine nitrogen mustard ethyl ester hydrochloride; L-Phenylalanine, 4-[bis(2-chloroethyl)amino]-, ethyl ester, hydrochloride; 4-[Bis(2-chloroethyl)amino]-DL-phenylalanine ethyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our 4-[Bis-(2-Chloro-Ethyl)-Amino]-Dl-Phenylalanine Ethyl Ester, Monohydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under anhydrous conditions. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.