Description

5-[Bis(2-Chloroethyl)Amino]-1-Methyl-1H-Benzimidazole-2-Butanoic Acid Methyl Ester is a specialized nitrogen mustard derivative of benzimidazole, designed for advanced pharmaceutical research and development. This compound is valued for its potential as a key synthetic intermediate in the creation of novel therapeutic agents, particularly in oncology and targeted drug delivery systems. It serves the critical needs of pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in medicinal chemistry and anticancer drug discovery.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel nitrogen mustard-based chemotherapeutic agents and prodrugs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new anticancer compounds with targeted mechanisms of action.
• Bioconjugation Studies: Serves as a reactive moiety for attaching cytotoxic payloads to antibodies, peptides, or other targeting ligands in antibody-drug conjugate (ADC) development.
• Biochemical Probe: Utilized in research to study alkylating agent interactions with DNA and cellular proteins.
• Fine Chemical Synthesis: An advanced intermediate for custom synthesis services catering to the pharmaceutical and biotechnology industries.

Basic Information

Product Name	5-[Bis(2-Chloroethyl)Amino]-1-Methyl-1H-Benzimidazole-2-Butanoic Acid Methyl Ester
CAS No.	109882-25-9
Molecular Formula	C₁₇H₂₃Cl₂N₃O₂
Molecular Weight	372.29 g/mol
Synonyms	Methyl 5-[bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoate; 1-Methyl-5-[bis(2-chloroethyl)amino]-1H-benzimidazole-2-butanoic Acid Methyl Ester; Benzimidazole-2-butanoic acid, 5-[bis(2-chloroethyl)amino]-1-methyl-, methyl ester; Nitrogen mustard benzimidazole ester
EINECS	Contact for details

Quality Control

Our production of this high-purity intermediate adheres to stringent quality protocols. Each batch is characterized and tested to ensure identity, purity, and consistency, supported by a comprehensive Certificate of Analysis (COA). We operate under a quality management system and can supply material suitable for research and development under cGMP conditions where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.