Description

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-, 5-oxide, (6R,7R)- (9CI) is a complex, high-purity pharmaceutical intermediate and reference standard. This compound is critical for research and development in advanced antibiotic synthesis, particularly for novel cephalosporin derivatives. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions focused on antimicrobial drug discovery and analytical method development.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced-generation cephalosporin antibiotics.
• Reference Standard: Used for analytical method development, validation, and quality control (QC/QA) in pharmaceutical manufacturing.
• Research & Development: Essential for structure-activity relationship (SAR) studies and the discovery of new antimicrobial agents with enhanced efficacy.
• Process Chemistry: Serves as a starting material or intermediate in scale-up and process optimization for active pharmaceutical ingredient (API) production.
• Academic Research: Utilized in university and institutional labs for studies in medicinal chemistry, organic synthesis, and microbiology.
• Regulatory Submissions: Provides a characterized compound for use in regulatory filings and documentation for new drug applications.

Basic Information

Product Name	5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-, 5-oxide, (6R,7R)- (9CI)
CAS No.	97466-28-9
Molecular Formula	C18H18N8O7S3
Molecular Weight	554.58 g/mol
Synonyms	(6R,7R)-7-[(Z)-2-(2-Aminothiazol-4-yl)-2-methoxyiminoacetamido]-8-oxo-3-[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-ylthio)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 5-Oxide; Cefmatilen; Cefmatilen Hydrochloride Intermediate; S-1090; 7β-[(Z)-2-(2-Aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-ylthio)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 5-Oxide; (6R-cis)-7-[[(2Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 5-Oxide
EINECS	Contact for details

Quality Control

This high-value intermediate is produced under strict quality management systems to ensure batch-to-batch consistency and traceability. Quality is verified through comprehensive analytical testing including HPLC, NMR, and mass spectrometry to confirm identity, purity, and stereochemical integrity. A detailed Certificate of Analysis (COA) is provided with each batch, documenting all critical parameters. Our production adheres to cGMP guidelines where applicable, supporting its use in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.2%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Optical Rotation	Specific range provided on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.