Description

Ceftriaxone Sodium CAS NO 104376-79-6 is a broad-spectrum, third-generation cephalosporin antibiotic belonging to the β-lactam class. It is valued for its potent bactericidal activity against a wide range of Gram-positive and Gram-negative pathogens, including many resistant strains. This active pharmaceutical ingredient (API) is essential for the formulation of injectable antibiotic preparations used in hospital and clinical settings worldwide.

Application

• Pharmaceutical API: Primary use as the active ingredient in sterile injectable formulations (powder for solution).
• Treatment of Bacterial Infections: Effective for severe infections including meningitis, sepsis, pneumonia, and complicated urinary tract infections.
• Hospital & Clinical Use: Critical for intravenous (IV) and intramuscular (IM) administration in inpatient and outpatient care.
• Surgical Prophylaxis: Used to prevent post-operative infections in various surgical procedures.
• Veterinary Medicine: Formulated for the treatment of bacterial infections in animals.
• Research & Development: Serves as a reference standard and for the development of new antibiotic formulations or combination therapies.

Basic Information

Product Name	Ceftriaxone Sodium
CAS No.	104376-79-6
Molecular Formula	C18H16N8Na2O7S3 • 3.5 H2O
Molecular Weight	661.59 g/mol (anhydrous basis)
Synonyms	Ceftriaxone Sodium Salt; (6R,7R)-7-[[(2Z)-(2-Aminothiazol-4-yl)(methoxyimino)acetyl]amino]-3-[[(2-methyl-6-sulfo-1,2,3-thiadiazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Sodium Salt; Rocephin (Brand Name); Cefatriaxone Sodium; Cephriaxone Sodium; Antibiotic Ro 13-9904; EINECS 233-468-1

Quality Control

Our Ceftriaxone Sodium is manufactured under strict quality management systems. It is tested to meet or exceed relevant pharmacopoeial standards, including USP, EP, and BP monographs. Each batch undergoes comprehensive analytical testing for identity, purity, potency, and specified impurities. A Certificate of Analysis (COA) documenting all test results is provided with every shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term stability, storage under an inert atmosphere (nitrogen) is recommended.

Specification

Item	Specification
Description	White to slightly yellowish crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC, anhydrous)	96.0% - 102.0%
pH (1% solution)	6.0 - 8.0
Water Content (KF)	8.0% - 11.0%
Specific Optical Rotation	-165° to -180°
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%
Residual Solvents (GC)	Complies with ICH Q3C
Bacterial Endotoxins	< 0.20 EU/mg
Sterility (for sterile grade)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.