Description

Cephalothin CAS NO 153-61-7 is a first-generation, semi-synthetic cephalosporin antibiotic derived from cephalosporin C. This compound is a critical active pharmaceutical ingredient (API) valued for its broad-spectrum bactericidal activity against a wide range of Gram-positive and some Gram-negative bacteria. It is primarily required by pharmaceutical manufacturers for the formulation of sterile injectable antibiotics, serving as a cornerstone in the treatment of serious infections in hospital and clinical settings.

Application

• Pharmaceutical API: Primary use as the active ingredient in the manufacture of sterile injectable cephalothin sodium formulations.
• Antibiotic Production: Serves as a key intermediate in the synthesis of other cephalosporin derivatives and antibiotic compounds.
• Clinical Research: Used as a reference standard in microbiological assays and pharmacological studies to evaluate antibacterial efficacy.
• Veterinary Medicine: Employed in the development of antibiotic treatments for bacterial infections in animals.
• Laboratory Reagent: Utilized in research laboratories for studying bacterial resistance mechanisms and β-lactamase activity.

Basic Information

Product Name	Cephalothin
CAS No.	153-61-7
Molecular Formula	C16H16N2O6S2
Molecular Weight	396.44 g/mol
Synonyms	Cephalothin; Cefalotin; 7-(Thiophene-2-acetamido)cephalosporanic acid; Keflin (trade name); Cephalothinum; Cephalotin; Cefalotinum; (6R,7R)-3-[(Acetyloxy)methyl]-7-[2-(2-thienyl)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
EINECS	205-816-3

Quality Control

Our Cephalothin is manufactured under strict quality management systems to meet the rigorous standards required for pharmaceutical active ingredients. Each batch is subjected to comprehensive analytical testing, including identification, purity assay, and impurity profiling via HPLC, to ensure compliance with relevant pharmacopeial monographs (e.g., USP, EP). A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and quality assurance for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term stability, storage under an inert atmosphere is recommended.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Microbial Enumeration	Meets Ph. Eur. 2.6.12 / USP <61> requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.