Description

(6R-Trans)-1-[[2-Carboxy-8-Oxo-7-[(2-Thienylacetyl)Amino]-5-Thia-1-Azabicyclo[4.2.0]Oct-2-En-3-Yl]Methyl]Pyridinium Thiocyanate is a high-purity pharmaceutical intermediate and reference standard, primarily known for its role in the synthesis and analysis of cephalosporin antibiotics. This compound is critical for ensuring the quality, efficacy, and regulatory compliance of advanced β-lactam antimicrobial agents. It is essential for research institutions, pharmaceutical manufacturers, and quality control laboratories engaged in antibiotic development, production, and analytical method validation.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced-generation cephalosporin antibiotics.
• Analytical Reference Standard: Used for quality control, method development, and validation in HPLC, LC-MS, and other chromatographic assays for cephalosporin APIs and finished drug products.
• Research & Development: Serves as a crucial reagent in medicinal chemistry for studying structure-activity relationships (SAR) and developing new β-lactam derivatives.
• Impurity Profiling: Employed as a marker to identify, quantify, and control process-related impurities and degradation products in cephalosporin manufacturing.
• Regulatory Compliance: Supports regulatory filings (e.g., FDA, EMA) by providing a characterized standard for identity, assay, and impurity testing.
• Academic Research: Used in biochemical and microbiological studies to investigate the mechanism of action and resistance of β-lactam antibiotics.

Basic Information

Product Name	(6R-Trans)-1-[[2-Carboxy-8-Oxo-7-[(2-Thienylacetyl)Amino]-5-Thia-1-Azabicyclo[4.2.0]Oct-2-En-3-Yl]Methyl]Pyridinium Thiocyanate
CAS No.	10353-05-6
Molecular Formula	C22H20N4O5S2 • SCN
Molecular Weight	Contact for details
Synonyms	7-(2-Thienylacetamido)cephalosporanic Acid Pyridinium Thiocyanate; Thiocyanic Acid Salt of 7-(2-Thienylacetamido)cephalosporanic Acid Pyridinium; Cephalothin Pyridinium Thiocyanate; Cephalothin Intermediate; 7-ACA Derivative Pyridinium Salt; (6R,7R)-3-(Pyridin-1-ium-1-ylmethyl)-8-oxo-7-(2-thiophene-2-ylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate thiocyanate
EINECS	Contact for details

Quality Control

Our (6R-Trans)-1-[[2-Carboxy-8-Oxo-7-[(2-Thienylacetyl)Amino]-5-Thia-1-Azabicyclo[4.2.0]Oct-2-En-3-Yl]Methyl]Pyridinium Thiocyanate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and assay, spectroscopic identification (IR, NMR), and residual solvent analysis, to ensure it meets stringent specifications for pharmaceutical use. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.