Description

(6R,7R)-3-[(Acetyloxy)Methyl]-8-Oxo-7-[(Phenoxyacetyl)Amino]-5-Thia-1-Azabicyclo[4.2.0]Octane-2-Ene-2-Carboxylic Acid CAS NO 10390-44-0 is a key pharmaceutical intermediate, specifically a cephalosporin nucleus derivative. This compound is of critical importance for the synthesis of advanced β-lactam antibiotics, offering a foundational building block for creating potent antimicrobial agents. It is primarily needed by manufacturers in the pharmaceutical and fine chemical industries engaged in the research, development, and production of active pharmaceutical ingredients (APIs).

Application

This cephalosporin intermediate serves as a crucial precursor in the synthesis of various antibiotic agents. Its primary applications include:

• Active Pharmaceutical Ingredient (API) Synthesis: Core building block for manufacturing second and third-generation cephalosporin antibiotics.
• Pharmaceutical Research & Development: Used in medicinal chemistry for developing new antibiotic compounds and studying structure-activity relationships (SAR).
• Process Chemistry: Employed in scaling up and optimizing synthetic routes for commercial antibiotic production.
• Fine Chemical Manufacturing: Serves as a high-value intermediate for custom synthesis and contract manufacturing organizations (CMOs).
• Reference Standard: Can be utilized as a chromatographic standard for quality control and analytical method development in pharmaceutical labs.

Basic Information

Product Name	(6R,7R)-3-[(Acetyloxy)Methyl]-8-Oxo-7-[(Phenoxyacetyl)Amino]-5-Thia-1-Azabicyclo[4.2.0]Octane-2-Ene-2-Carboxylic Acid
CAS No.	10390-44-0
Molecular Formula	C19H18N2O7S
Molecular Weight	418.42 g/mol
Synonyms	7-ADCA Phenoxyacetyl Derivative; 7-Phenoxyacetamido-3-acetoxymethyl-3-cephem-4-carboxylic Acid; 7-[(Phenoxyacetyl)Amino]-3-(Acetoxymethyl)-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid; 7-PACA; Cephalosporanic Acid Derivative; Phenoxyacetyl-7-ADCA; Antibiotic Intermediate 10390-44-0; 7-ACA Phenoxyacetyl Ester Analog
EINECS	Contact for details

Quality Control

Our (6R,7R)-3-[(Acetyloxy)Methyl]-8-Oxo-7-[(Phenoxyacetyl)Amino]-5-Thia-1-Azabicyclo[4.2.0]Octane-2-Ene-2-Carboxylic Acid is produced under a strict quality management system. Every batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing key parameters such as assay, related substances, and residual solvents. Specifications can be aligned with pharmaceutical grade requirements for API synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Recommended long-term storage temperature is 2-8°C (refrigerated). For short-term or in-process handling, maintain at controlled room temperature (15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.