Description

(6R,7R)-7-[[(2Z)-2-(carboxymethoxyamino)-2-pyrazol-3-ylidene-acetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid is a key advanced pharmaceutical intermediate, specifically a cephalosporin nucleus derivative. This compound is critical for the synthesis of next-generation β-lactam antibiotics, offering a sophisticated chemical backbone for developing potent antimicrobial agents. It is primarily required by pharmaceutical R&D laboratories and active pharmaceutical ingredient (API) manufacturers targeting complex bacterial infections.

Application

• Pharmaceutical Intermediate: Core building block for the synthesis of advanced cephalosporin antibiotics.
• Antibiotic R&D: Used in research and development of new antibacterial agents with enhanced efficacy and spectrum.
• API Synthesis: Critical intermediate in the multi-step manufacturing process of final Active Pharmaceutical Ingredients (APIs).
• Structure-Activity Relationship (SAR) Studies: Employed in medicinal chemistry to explore modifications for optimizing antibiotic potency and pharmacokinetics.
• Process Chemistry Development: Serves as a reference standard and starting material for scaling up and optimizing synthetic routes.

Basic Information

Product Name	(6R,7R)-7-[[(2Z)-2-(carboxymethoxyamino)-2-pyrazol-3-ylidene-acetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS No.	84080-55-7
Molecular Formula	C18H18N8O7S2
Molecular Weight	522.51 g/mol
Synonyms	7β-[2-(Carboxymethoxyimino)-2-(1H-pyrazol-3-yl)acetamido]-3-[(1-methyl-1H-tetrazol-5-yl)thiomethyl]-3-cephem-4-carboxylic Acid; Cephalosporin 84080-55-7; 7-ACA derivative with pyrazole and MTZ side chains; (6R,7R)-3-[(1-Methyl-1H-tetrazol-5-yl)thiomethyl]-7-[2-(1H-pyrazol-3-yl)-2-(carboxymethoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
EINECS	Contact for details

Quality Control

Our pharmaceutical-grade intermediates are produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of residual solvents and impurities to meet ICH guidelines. A detailed Certificate of Analysis (COA) is provided with every shipment to ensure traceability and compliance with your R&D or cGMP manufacturing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. Ensure the storage area is well-ventilated.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH limits
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.