Description

Sodium (6R,7R)-7-[[2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-acetyl] amino]-8-oxo-3-(thiadiazol-5-ylsulfanylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate is a high-purity, non-sterile pharmaceutical intermediate, specifically the sodium salt of a third-generation cephalosporin antibiotic. This compound is critical for ensuring the efficacy and safety of final active pharmaceutical ingredients (APIs) used in broad-spectrum antibacterial formulations. It is primarily required by manufacturers in the pharmaceutical and fine chemical industries for the synthesis of advanced antibiotic products.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of third-generation cephalosporin antibiotics.
• Active Pharmaceutical Ingredient (API) Manufacturing: Used in the production of final antibiotic drug substances for injectable formulations.
• Research & Development: Serves as a reference standard and starting material in antimicrobial research and new drug development.
• Fine Chemical Synthesis: Employed in specialized organic synthesis for creating complex β-lactam structures.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production.

Basic Information

Product Name	Sodium (6R,7R)-7-[[2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-acetyl] amino]-8-oxo-3-(thiadiazol-5-ylsulfanylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
CAS No.	82219-81-6
Molecular Formula	C18H15N8NaO6S4
Molecular Weight	590.61 g/mol
Synonyms	Ceftriaxone Sodium Impurity; Sodium Ceftriaxone Intermediate; (6R,7R)-7-[(Z)-2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetamido]-3-[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Sodium Salt; Ceftriaxone Sodium Salt Impurity; 82219-81-6 (Sodium Salt); Sodium 7-(2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido)-3-(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-as-triazin-3-ylthiomethyl)-3-cephem-4-carboxylate
EINECS	Contact for details

Quality Control

Our sodium ceftriaxone intermediate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your regulatory compliance and quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.