Description

5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid,7-((5-amino-5-carboxy-1-oxopentyl)amino)-3-(hydroxymethyl)-7-methoxy-, monosodium salt , (6R-(6alpha,7beta(R*)))- is a high-purity pharmaceutical intermediate and reference standard of critical importance in the synthesis and quality control of advanced β-lactam antibiotics. This compound, supplied with CAS No. 81517-91-1, is essential for research, development, and manufacturing processes where precise chemical structure and purity are non-negotiable. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and analytical laboratories engaged in the production and analysis of cephalosporin-class drugs.

Application

• Pharmaceutical Intermediate: A key building block in the synthetic pathway for specific cephalosporin antibiotics.
• Reference Standard: Used for analytical method development, validation, and quality control (QC) testing of active pharmaceutical ingredients (APIs) and finished drug products.
• Research & Development: Serves as a crucial reagent in medicinal chemistry for the design and synthesis of novel β-lactam compounds with potential therapeutic activity.
• Impurity Profiling: Employed as a certified reference material to identify, quantify, and control process-related impurities and degradation products in antibiotic formulations.
• Regulatory Submissions: Provides essential chemical identity and purity data to support regulatory filings (e.g., with FDA, EMA) for new drug applications (NDAs) and marketing authorizations.

Basic Information

Product Name	5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid,7-((5-amino-5-carboxy-1-oxopentyl)amino)-3-(hydroxymethyl)-7-methoxy-, monosodium salt , (6R-(6alpha,7beta(R*)))-
CAS No.	81517-91-1
Molecular Formula	C16H22N3NaO8S
Molecular Weight	439.42 g/mol
Synonyms	(6R,7R)-7-[(R)-2-Amino-2-carboxyethylthioacetamido]-3-(hydroxymethyl)-7-methoxyceph-3-em-4-carboxylic acid sodium salt; Sodium (6R,7R)-7-[(R)-2-amino-2-carboxyethylthioacetamido]-3-(hydroxymethyl)-7-methoxy-3-cephem-4-carboxylate; Cefmetazole sodium impurity; Cefmetazole related compound; 7-Methoxy-7-[(R)-2-(2-amino-2-carboxyethylthio)acetamido]-3-(hydroxymethyl)-3-cephem-4-carboxylic acid sodium salt; Antibiotic intermediate; Cephalosporin nucleus derivative.
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, spectroscopic identification (IR, NMR), and tests for residual solvents and specific impurities to ensure it meets exacting standards for pharmaceutical use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support compliance with cGMP, ICH Q7, and other relevant pharmaceutical guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.