Description

(6R,7S)-7-[[(2R,3S)-2-(4-Ethyl-2,3-dioxo-1-piperazinylcarbonylamino)-3-hydroxybutyryl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid is a high-purity advanced pharmaceutical intermediate, specifically a cephalosporin nucleus derivative. This compound is critical for the synthesis of third-generation cephalosporin antibiotics, offering a key structural component for developing potent antimicrobial agents. It is essential for pharmaceutical manufacturers and R&D facilities focused on antibiotic development, API synthesis, and novel drug formulation.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Core intermediate for the production of third-generation cephalosporin antibiotics.
• Pharmaceutical Research & Development: Used in medicinal chemistry for the design and synthesis of new β-lactam antibiotic candidates.
• Generic Drug Manufacturing: A key starting material in the production of generic cephalosporin drugs.
• Contract Manufacturing Organizations (CMOs): Supplied to CMOs specializing in antibiotic production for global markets.
• Chemical Reference Standard: Serves as a high-purity standard for analytical method development and quality control in pharmaceutical labs.
• Academic & Institutional Research: Utilized in biochemical and microbiological studies investigating antibiotic mechanisms of action and resistance.

Basic Information

Item	Details
Product Name	(6R,7S)-7-[[(2R,3S)-2-(4-Ethyl-2,3-dioxo-1-piperazinylcarbonylamino)-3-hydroxybutyryl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS No.	76610-92-9
Molecular Formula	C20H26N8O8S2
Molecular Weight	570.60 g/mol
Synonyms	7-ACA derivative with tetrazolethio and piperazine side chain; 7β-[2-(4-Ethyl-2,3-dioxo-1-piperazinylcarboxamido)-2-hydroxyacetamido]-3-[(1-methyl-1H-tetrazol-5-yl)thiomethyl]-3-cephem-4-carboxylic acid; Cephalosporin C-7 side chain intermediate; 7-ADCA derivative; (6R,7S)-3-[(1-Methyl-1H-tetrazol-5-ylthio)methyl]-7-[2-(4-ethyl-2,3-dioxopiperazine-1-carboxamido)-2-hydroxyacetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our (6R,7S)-7-[[(2R,3S)-2-(4-Ethyl-2,3-dioxo-1-piperazinylcarbonylamino)-3-hydroxybutyryl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid is manufactured under strict quality management systems. Production adheres to cGMP (current Good Manufacturing Practice) guidelines where applicable, ensuring traceability and batch-to-batch consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Long-term storage under inert atmosphere (e.g., nitrogen) is recommended for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Optical Rotation	Specific range provided per batch on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.