Description

(6R)-7α-[[(R)-5-Amino-5-carboxy-1-oxopentyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid is a high-purity, advanced pharmaceutical intermediate, specifically a cephalosporin derivative. This compound is critical for the synthesis of next-generation β-lactam antibiotics, offering a key structural moiety for enhanced antimicrobial activity and stability. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development and production of novel antibacterial agents.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a crucial building block in the multi-step synthesis of advanced cephalosporin antibiotics.
• Pharmaceutical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies to develop new antibacterial compounds with improved efficacy.
• Process Chemistry & Scale-Up: Employed in optimizing synthetic routes for the commercial-scale manufacturing of cephalosporin drugs.
• Reference Standard: Functions as a high-purity analytical standard for quality control and regulatory testing of finished pharmaceutical products.
• Biochemical Research: Utilized in studies investigating the mechanism of action and resistance patterns of β-lactam antibiotics.

Basic Information

Product Name	(6R)-7α-[[(R)-5-Amino-5-carboxy-1-oxopentyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS No.	75765-45-6
Molecular Formula	C₁₉H₂₄N₈O₇S₂
Molecular Weight	540.57 g/mol
Synonyms	7-Methoxy-3-[(1-methyl-1H-tetrazol-5-ylthio)methyl]cepham; Cefmetazole Intermediate; (6R,7R)-7-[[(R)-2-Amino-2-carboxyethyl]thioacetamido]-7-methoxy-3-[(1-methyl-1H-tetrazol-5-yl)thiomethyl]-3-cephem-4-carboxylic Acid; Cefmetazole Side Chain; 7α-Methoxy-7β-(2-aminothiazol-4-ylacetamido)-3-[(1-methyl-1H-tetrazol-5-yl)thiomethyl]cepham-4-carboxylic Acid Derivative; Antibiotic Intermediate 75765-45-6
EINECS	Contact for details

Quality Control

Our (6R)-7α-[[(R)-5-Amino-5-carboxy-1-oxopentyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing including HPLC for purity, NMR and IR for structural confirmation, and comprehensive residual solvent analysis to ensure compliance with ICH guidelines and customer-specific requirements. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency. For long-term storage, consider refrigeration at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C limits
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.