Description

(1R)-2,3,9a,12aα-Tetrahydro-9aβ-hydroxy-8-(hydroxymethyl)-1α,11-dimethyl-3α-(1-methylethenyl)-5-(phenylmethyl)-5α,12bα-epoxy-3,6aβ-methano-1H-azuleno[5,4-d][1,3]dioxocin-10(9H)-one is a complex, high-value organic compound with a unique polycyclic structure, serving as a critical advanced pharmaceutical intermediate or reference standard. Its intricate stereochemistry and functional groups make it a valuable building block for the synthesis of novel active pharmaceutical ingredients (APIs). This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly in specialized areas of medicinal chemistry.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the research and development of novel, complex drug candidates, particularly in oncology and anti-infective therapeutic areas.
• Reference Standard: Used for analytical method development, validation, and quality control (QC) in pharmaceutical laboratories to ensure the identity and purity of related substances.
• Medicinal Chemistry Research: Serves as a core scaffold or a sophisticated synthon for structure-activity relationship (SAR) studies and lead optimization programs.
• Process Chemistry Development: Employed in route scouting and scale-up studies for the synthesis of target molecules with similar complex architectures.
• Academic Research: Used in university and institutional labs for studies in organic synthesis, total synthesis projects, and exploring new chemical transformations.

Basic Information

Item	Details
Product Name	(1R)-2,3,9a,12aα-Tetrahydro-9aβ-hydroxy-8-(hydroxymethyl)-1α,11-dimethyl-3α-(1-methylethenyl)-5-(phenylmethyl)-5α,12bα-epoxy-3,6aβ-methano-1H-azuleno[5,4-d][1,3]dioxocin-10(9H)-one
CAS No.	75659-59-5
Molecular Formula	C30H36O6
Molecular Weight	492.61 g/mol
Synonyms	Paclitaxel Impurity 1; Taxol Impurity 1; 7-Epi-10-deacetylpaclitaxel; 10-Deacetyl-7-epipaclitaxel; 7-Epi-10-DAT; (1R,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-Diacetoxy-15-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0³,¹⁰.0⁴,⁷]heptadec-13-en-2-yl benzoate (related isomer); 7-Epi-10-deacetyl taxol; 10-Deacetyl-7-epi-taxol
EINECS	Contact for details

Quality Control

Every batch of (1R)-2,3,9a,12aα-Tetrahydro-9aβ-hydroxy-8-(hydroxymethyl)-1α,11-dimethyl-3α-(1-methylethenyl)-5-(phenylmethyl)-5α,12bα-epoxy-3,6aβ-methano-1H-azuleno[5,4-d][1,3]dioxocin-10(9H)-one is produced and analyzed under strict quality management systems. We provide comprehensive analytical data to support its use in regulated environments. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles by HPLC, NMR, and MS are available for each lot, ensuring traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.