Description

3-Bromo-5-Fluoro-2-Methoxypyridine is a high-purity halogenated pyridine derivative, a crucial building block in modern synthetic organic chemistry. Its value lies in its unique substitution pattern, which provides versatile reactivity for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel active pharmaceutical ingredients (APIs), especially in drug discovery programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides, where the bromo and fluoro substituents enhance biological activity and stability.
• Material Science Precursor: Serves as a building block for creating functionalized ligands, organic semiconductors, and liquid crystal materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to form biaryl and other complex structures.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D labs for methodological studies and library synthesis in medicinal chemistry.

Basic Information

Product Name	3-Bromo-5-Fluoro-2-Methoxypyridine
CAS No.	884494-81-9
Molecular Formula	C6H5BrFNO
Molecular Weight	206.01 g/mol
Synonyms	3-Bromo-5-fluoro-2-methoxypyridine; 2-Methoxy-3-bromo-5-fluoropyridine; 5-Fluoro-3-bromo-2-methoxypyridine; 884494-81-9; 3-Bromo-5-fluoro-2-pyridinol methyl ether
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-Fluoro-2-Methoxypyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring consistency and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.