Description

(R)-2-Amino-3-(5-Fluoro-1H-Indol-3-Yl)-Propionic Acid is a chiral, non-proteinogenic amino acid derivative featuring a fluorinated indole moiety, making it a valuable synthetic building block for advanced research and development. This compound is critical for the synthesis of novel bioactive molecules, particularly in the pharmaceutical sector where its specific stereochemistry and functional groups are leveraged. It is primarily sought after by medicinal chemists and research institutions engaged in developing peptide-based therapeutics, enzyme inhibitors, and targeted drug discovery programs.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of novel drug candidates, especially for central nervous system (CNS) and oncology targets.
• Peptidomimetic Research: Used to incorporate fluorinated indole scaffolds into peptide analogs to enhance metabolic stability, bioavailability, and binding affinity.
• Enzyme Inhibitor Development: Serves as a core structure for designing potent and selective inhibitors of tryptophan-related enzymes.
• Bioconjugation & Probe Synthesis: Utilized in creating fluorescent or affinity probes for biochemical and cellular imaging studies.
• Academic & Contract Research: Essential reagent for fundamental research in organic chemistry, medicinal chemistry, and chemical biology.
• Process Chemistry & Scale-Up: Sourced for route development and optimization during the pre-clinical to clinical transition of new chemical entities.

Basic Information

Product Name	(R)-2-Amino-3-(5-Fluoro-1H-Indol-3-Yl)-Propionic Acid
CAS No.	97749-24-1
Molecular Formula	C11H11FN2O2
Molecular Weight	222.22 g/mol
Synonyms	(R)-5-Fluorotryptophan; D-5-Fluorotryptophan; (R)-5-F-Trp; (2R)-2-Amino-3-(5-fluoro-1H-indol-3-yl)propanoic acid; 5-Fluoro-D-tryptophan; (R)-α-Amino-1H-indole-3-propanoic acid, 5-fluoro-; 5-Fluoro-(R)-tryptophan; D-5-Fluoro-Trp
EINECS	Contact for details

Quality Control

Our (R)-2-Amino-3-(5-Fluoro-1H-Indol-3-Yl)-Propionic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) providing full specifications, including assay, enantiomeric excess, and impurity profiles, is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.