Description

(6R-(6-alpha,7-alpha))-7-((((2-Amino-2-carboxyethyl)thio)acetyl)amino)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid monosodium salt is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) of significant commercial importance. This compound is a key derivative in the synthesis of advanced cephalosporin antibiotics, offering a critical building block for modern antimicrobial formulations. It is essential for pharmaceutical manufacturers and research institutions focused on developing and producing next-generation β-lactam antibiotics to combat resistant bacterial strains.

Application

• Pharmaceutical API Synthesis: Primary use as a critical intermediate in the industrial-scale production of third and fourth-generation cephalosporin antibiotics.
• Antibiotic Research & Development: Serves as a key precursor in R&D laboratories for creating novel β-lactam structures with enhanced efficacy and spectrum of activity.
• Generic Drug Manufacturing: Used in the formulation of generic versions of established cephalosporin drugs, ensuring cost-effective therapeutic options.
• Veterinary Medicine: Applied in the synthesis of broad-spectrum antibiotics for veterinary use, targeting bacterial infections in livestock and companion animals.
• Biochemical Research: Utilized as a standard or reference compound in studies investigating bacterial cell wall synthesis and the mechanism of action of β-lactam drugs.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and clinical trial material production.

Basic Information

Product Name	(6R-(6-alpha,7-alpha))-7-((((2-Amino-2-carboxyethyl)thio)acetyl)amino)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid monosodium salt
CAS No.	75498-96-3
Molecular Formula	C18H21N8NaO7S3
Molecular Weight	580.59 g/mol
Synonyms	Cefmetazole Sodium EP Impurity C; Cefmetazole Sodium Related Compound C; Sodium (6R,7S)-7-[[(2S)-2-amino-2-carboxyethyl]thio]acetamido]-7-methoxy-3-[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; Cefmetazole Sodium Impurity; 7-Methoxy Cefmetazole Derivative; Cefmetazole Intermediate; Antibiotic Intermediate 75498-96-3
EINECS	Contact for details

Quality Control

Our production of this high-value pharmaceutical intermediate adheres to strict cGMP (current Good Manufacturing Practice) guidelines to ensure batch-to-batch consistency and traceability. Quality is verified through a comprehensive suite of analytical methods including HPLC for purity and impurity profiling, spectroscopic identification, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with agreed specifications. We support compliance with major pharmacopoeial standards (USP, EP, JP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under conditions that minimize exposure to atmospheric humidity to prevent degradation and ensure stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.