Description

(E)-2-Hydroxymethyl-2-butenoic acid [(1aR,3R,4Z,5aR,8aR,9R,10aR)-3-acetoxy-1a,2,3,5a,7,8,8a,9,10,10a-decahydro-4,10a-dimethyl-8-methylene-7-oxooxireno[5,6]cyclodeca[1,2-b]furan-9-yl] ester is a complex, high-purity chemical intermediate with a defined stereochemistry, making it a valuable building block for advanced synthesis. This compound is critical for research and development in the pharmaceutical sector, particularly for the synthesis of novel therapeutic agents and complex natural product derivatives. It is primarily sought by fine chemical manufacturers, pharmaceutical R&D laboratories, and academic institutions working on cutting-edge organic synthesis and medicinal chemistry projects.

Application

• Pharmaceutical Intermediate: Key precursor in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a sophisticated scaffold or building block for structure-activity relationship (SAR) studies and lead optimization.
• Natural Product Synthesis: Serves as a critical intermediate in the total or semi-synthesis of complex natural products with biological activity.
• Process Chemistry Development: Employed in route scouting and scale-up studies for the efficient production of high-value target molecules.
• Bioconjugation & Probe Development: Potential use in creating labeled compounds or probes for biochemical and diagnostic applications due to its reactive ester functionality.
• Academic & Institutional Research: Utilized in advanced organic chemistry laboratories for methodological development and the exploration of new chemical transformations.

Basic Information

Product Name	(E)-2-Hydroxymethyl-2-butenoic acid [(1aR,3R,4Z,5aR,8aR,9R,10aR)-3-acetoxy-1a,2,3,5a,7,8,8a,9,10,10a-decahydro-4,10a-dimethyl-8-methylene-7-oxooxireno[5,6]cyclodeca[1,2-b]furan-9-yl] ester
CAS No.	72984-74-8
Molecular Formula	C23H30O8
Molecular Weight	434.48 g/mol
Synonyms	Artemisinin derivative ester; (E)-2-(Hydroxymethyl)-2-butenoic acid artemisinin ester; 2-Butenoic acid, 2-(hydroxymethyl)-, (1aR,3R,4Z,5aR,8aR,9R,10aR)-3-(acetyloxy)-1a,2,3,5a,7,8,8a,9,10,10a-decahydro-4,10a-dimethyl-8-methylene-7-oxooxireno[5,6]cyclodeca[1,2-b]furan-9-yl ester, (E)-; Artemisinin (E)-2-hydroxymethyl-2-butenoate; Dihydroartemisinin derivative; Arteether analogue; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and MS to confirm identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development and commercial projects requiring compliance with cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a dry, well-ventilated area. This material is light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single unknown impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.