Description

(3R)-4,5-Dihydro-3β-(3-furyl)-7-[[(2S,4S)-4-[(2S)-2,5-dihydro-2-methyl-5-oxofuran-2-yl]-2-methoxy-5,5-dimethyltetrahydrofuran-2-yl]methyl]-3aβ,7aβ-methanoisobenzofuran-1(3H)-one is a high-purity, complex organic intermediate characterized by its intricate fused ring system containing multiple stereocenters. This compound is of significant commercial interest for its role as a critical building block in advanced pharmaceutical synthesis, particularly for the development of novel therapeutic agents. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the synthesis of complex molecules, where precise stereochemistry and high purity are paramount for successful outcomes.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for complex target molecules.
• Medicinal Chemistry Research: Used as a sophisticated scaffold or precursor in drug discovery programs to explore new chemical entities and structure-activity relationships.
• Process Chemistry Development: Serves as a critical intermediate in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Asymmetric Synthesis: Utilized in stereoselective synthesis due to its defined stereocenters, enabling the construction of enantiomerically pure compounds.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-fidelity intermediates.
• Academic Research: Employed in university and institutional labs for methodological studies in organic synthesis and catalysis.

Basic Information

Item	Details
Product Name	(3R)-4,5-Dihydro-3β-(3-furyl)-7-[[(2S,4S)-4-[(2S)-2,5-dihydro-2-methyl-5-oxofuran-2-yl]-2-methoxy-5,5-dimethyltetrahydrofuran-2-yl]methyl]-3aβ,7aβ-methanoisobenzofuran-1(3H)-one
CAS No.	70449-71-7
Molecular Formula	C28H32O8
Molecular Weight	496.55 g/mol
Synonyms	Contact for details
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and purity suitable for pharmaceutical research. Certificates of Analysis (COA) are provided with each shipment, detailing key parameters such as assay, enantiomeric excess, and impurity profiles. While not a final API, our quality systems are designed to support development work under cGMP-aligned conditions where required, ensuring traceability and documentation for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is sensitive to strong acids and organic solvents; ensure storage areas are well-ventilated and segregated from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.