Description

(4-nitrophenyl)methyl [5R-[5alpha,6alpha(R*)]]-6-(1-hydroxyethyl)-3-[[2-[[[(4-nitrophenyl)methoxy]carbonyl]amino]ethyl]thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate is a sophisticated synthetic intermediate of significant importance in advanced pharmaceutical research and development. This compound is a key building block in the synthesis of complex β-lactam antibiotics, where its specific stereochemistry and functional groups are critical for biological activity. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel antibacterial agents and the study of enzyme inhibition mechanisms.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of advanced cephalosporin and penem class antibiotics.
• Antibacterial Research: Used in medicinal chemistry programs to develop new molecules targeting bacterial cell wall synthesis.
• β-Lactamase Inhibitor Studies: Serves as a core structure for designing compounds that counteract bacterial resistance mechanisms.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic assays to study the activity of bacterial transpeptidases and β-lactamases.
• Process Chemistry Development: Used for scaling up and optimizing synthetic routes for active pharmaceutical ingredients (APIs).
• Academic Research: A valuable compound for university laboratories studying organic synthesis methodologies and heterocyclic chemistry.

Basic Information

Item	Details
Product Name	(4-nitrophenyl)methyl [5R-[5alpha,6alpha(R*)]]-6-(1-hydroxyethyl)-3-[[2-[[[(4-nitrophenyl)methoxy]carbonyl]amino]ethyl]thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
CAS No.	64067-13-6
Molecular Formula	C25H24N4O9S
Molecular Weight	556.55 g/mol
Synonyms	6-(1-Hydroxyethyl)-3-[[2-[[[(4-nitrophenyl)methoxy]carbonyl]amino]ethyl]thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid (4-Nitrophenyl)methyl Ester; (4-Nitrophenyl)methyl 6-(1-Hydroxyethyl)-3-[(2-{[(4-Nitrobenzyloxy)carbonyl]amino}ethyl)thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate; 4-Nitrobenzyl 6-(1-Hydroxyethyl)-3-[(2-{[(4-Nitrobenzyloxy)carbonyl]amino}ethyl)thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate; A Key Cephalosporin Intermediate; PNZ-Protected β-Lactam Intermediate
EINECS	Contact for details

Quality Control

We supply this high-value intermediate with a strong commitment to purity and batch-to-batch consistency, essential for sensitive pharmaceutical synthesis. Our quality assurance process includes rigorous analytical controls such as HPLC, NMR, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing specifications for assay, related substances, and residual solvents. Production can be aligned with cGMP guidelines for advanced research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.