Description

(2R)-4α-(Dimethylamino)-3,4,5,6,9,11,12,13,14,16-decahydro-3β,5β,8,10,13α-pentahydroxy-6,13-dimethyl-9,16-dioxo-2α,6α-epoxy-2H-naphthaceno[1,2-b]oxocin-14α-carboxylic acid methyl ester is a complex, semi-synthetic tetracycline derivative with significant biological activity. This compound is valued for its role as a key intermediate or active pharmaceutical ingredient (API) in advanced pharmaceutical research and development. It is primarily sought by pharmaceutical manufacturers and research institutions focused on developing novel antibacterial and potentially anti-inflammatory therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of next-generation tetracycline-class antibiotics.
• Active Pharmaceutical Ingredient (API) Development: Used in the research and formulation of new antibacterial drugs targeting resistant pathogens.
• Biochemical Research: Employed as a reference standard or probe in microbiological and pharmacological studies to investigate protein synthesis inhibition.
• Veterinary Medicine: Potential application in developing advanced treatments for bacterial infections in animals.
• Academic & Contract Research: Utilized in university and CRO laboratories for drug discovery programs and mechanism-of-action studies.

Basic Information

Item	Details
Product Name	(2R)-4α-(Dimethylamino)-3,4,5,6,9,11,12,13,14,16-decahydro-3β,5β,8,10,13α-pentahydroxy-6,13-dimethyl-9,16-dioxo-2α,6α-epoxy-2H-naphthaceno[1,2-b]oxocin-14α-carboxylic acid methyl ester
CAS No.	62422-00-8
Molecular Formula	C₂₈H₃₅NO₁₂
Molecular Weight	577.58 g/mol
Synonyms	Methacycline Methyl Ester; 6-Methylene-5-oxytetracycline methyl ester; 6-Deoxy-6-demethyl-6-methylene-5-oxytetracycline methyl ester; Metacycline Methyl Ester; 6-Methylene Oxytetracycline Methyl Ester; (2R,4S,4aR,5S,5aR,6S,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide Methyl Ester (related IUPAC); Antibiotic L 10178
EINECS	Contact for details

Quality Control

Our (2R)-4α-(Dimethylamino)-3,4,5,6,9,11,12,13,14,16-decahydro-3β,5β,8,10,13α-pentahydroxy-6,13-dimethyl-9,16-dioxo-2α,6α-epoxy-2H-naphthaceno[1,2-b]oxocin-14α-carboxylic acid methyl ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets stringent specifications for pharmaceutical use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed-upon standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.