Description

S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] 2-methyl-3-oxobutanethioate is a high-purity, complex biochemical intermediate of significant interest in advanced pharmaceutical research and development. This compound is valued for its role as a key building block in nucleotide-based therapeutics, enabling the synthesis of novel drug candidates. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers focused on antiviral, anticancer, and metabolic disease research.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of nucleotide analogs and prodrugs for antiviral and anticancer applications.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate metabolic pathways and signal transduction.
• Prodrug Development: Serves as a masked or activated form of therapeutic nucleotides, designed for improved bioavailability and targeted delivery.
• Antiviral Agent Synthesis: A key component in the research and development of novel nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral compounds.
• Labeled Compound Synthesis: Basis for creating isotopically labeled (e.g., 13C, 15N, 32P) versions for pharmacokinetic and metabolic tracing studies.
• Protecting Group Chemistry: The thioester moiety can be utilized in sophisticated multi-step organic syntheses requiring selective protection and deprotection strategies.

Basic Information

Item	Details
Product Name	S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] 2-methyl-3-oxobutanethioate
CAS No.	6712-01-2
Molecular Formula	C25H41N7O18P3S
Molecular Weight	876.66 g/mol
Synonyms	Coenzyme A, S-acetoacetyl; S-Acetoacetylcoenzyme A; Acetoacetyl-CoA; 3-Oxobutanoyl-CoA; Acetoacetyl coenzyme A; S-Acetoacetyl-CoA; Acetylacetyl coenzyme A; CoA S-acetoacetyl
EINECS	Contact for details

Quality Control

Our S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] 2-methyl-3-oxobutanethioate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for research-grade biochemicals. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.