Description

NADPH Tetrasodium Salt is the reduced, biologically active form of nicotinamide adenine dinucleotide phosphate (NADP+), a critical coenzyme in numerous metabolic pathways. This high-purity reagent is essential for driving reductive biosynthetic reactions and maintaining cellular redox balance. It is a fundamental component for research and production in pharmaceutical development, enzymatic diagnostics, and biochemical research, where a reliable and consistent supply is paramount for assay accuracy and process scalability.

Application

• Enzymatic Assays & Diagnostic Kits: Serves as an essential electron donor in a wide range of clinical and research enzyme-coupled reactions, including those for glucose-6-phosphate dehydrogenase.
• Pharmaceutical Research & Biocatalysis: Used as a cofactor in the development and scale-up of enzymatic processes for the synthesis of chiral intermediates and active pharmaceutical ingredients (APIs).
• Cell Culture & Metabolism Studies: Supports research into cellular metabolism, oxidative stress, and the function of NADPH-dependent enzymes like cytochrome P450 and nitric oxide synthase.
• Antioxidant Research: Critical for studies involving the glutathione and thioredoxin systems, which rely on NADPH to regenerate reduced antioxidants.
• Food & Beverage Analysis: Employed in enzymatic methods for the quantitative determination of various substrates in quality control laboratories.
• Industrial Biotechnology: Acts as a co-substrate in engineered metabolic pathways for the microbial production of fine chemicals and biofuels.

Basic Information

Product Name	NADPH Tetrasodium Salt
CAS No.	2646-71-1
Molecular Formula	C21H26N7Na4O17P3
Molecular Weight	833.36 g/mol (anhydrous basis)
Synonyms	β-NADPH Tetrasodium Salt; TPNH Tetrasodium Salt; Coenzyme II Reduced Tetrasodium Salt; Nicotinamide Adenine Dinucleotide Phosphate Reduced Tetrasodium Salt; Dihydronicotinamide Adenine Dinucleotide Phosphate Tetrasodium Salt; 2'-NADPH Na4; Reduced NADP Tetrasodium Salt
EINECS	220-168-1

Quality Control

Our NADPH Tetrasodium Salt is manufactured under strict quality management systems to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including HPLC for purity and enzymatic activity assays, to meet the stringent requirements of research and industrial applications. Certificates of Analysis (COA) detailing purity, identity, and specific activity are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant for long-term stability. This product is hygroscopic (moisture-sensitive). For short-term use, aliquots may be stored at 2-8°C. Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/UV)	Conforms
Purity (HPLC)	≥ 95%
Enzymatic Activity	≥ 90%
Water Content (KF)	≤ 5.0%
pH (1% Solution)	7.0 - 9.0
Filter Sterilization	Passes through 0.2 µm filter

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.