Description

S-Adenosyl-L-Methionine (SAMe) is a critical biochemical cofactor and methyl group donor essential for numerous cellular processes. Its primary commercial value lies in its role as a high-purity active pharmaceutical ingredient (API) for nutraceutical and pharmaceutical formulations. This compound is vital for manufacturers in the pharmaceutical, dietary supplement, and advanced research sectors seeking a reliable source for products supporting liver health, joint function, and mood regulation.

Application

• Pharmaceutical Active Ingredient (API): Used in prescription and over-the-counter medications for liver disorders (e.g., intrahepatic cholestasis), depression, and osteoarthritis.
• Dietary Supplement Formulation: A key ingredient in high-end nutraceuticals targeting joint health, mood support, and liver detoxification.
• Biochemical Research: Essential as a substrate in enzymatic studies, particularly for methyltransferases involved in epigenetics, neuroscience, and metabolic pathways.
• Cell Culture & Biotechnology: Used in media supplements to support methylation reactions and study cellular metabolism in vitro.
• Veterinary Pharmaceuticals: Incorporated into supplements for companion animals to support mobility and liver function.

Basic Information

Item	Details
Product Name	S-Adenosyl-L-Methionine
CAS No.	29908-03-0
Molecular Formula	C15H22N6O5S+
Molecular Weight	398.44 g/mol
Synonyms	SAMe; SAM; AdoMet; S-Adenosylmethionine; Ademetionine; (3S)-5'-[(3-Amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine; L-S-Adenosylmethionine; SAM-e
EINECS	Contact for details

Quality Control

Our S-Adenosyl-L-Methionine is manufactured under strict quality systems suitable for pharmaceutical and nutraceutical use. We provide material that meets relevant specifications for high-purity applications, with testing typically including assay, enantiomeric purity, and impurity profile analysis. Certificates of Analysis (COA) documenting batch-specific results are available upon request to ensure full traceability and compliance for your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This material is hygroscopic (moisture-sensitive) and easily oxidized; therefore, containers must be sealed immediately after use and kept under dry conditions. For short-term use, store at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	+47° to +52° (c=1 in 0.1N HCl)
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Microbiological Analysis	Meets Ph. Eur. / USP criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.